Though varying considerably in appearance (see gallery below), these species generally have thick, stout stems and fleshy leaves, sometimes with epidermal windows. Peperomia flowers typically come in yellow to brown conical spikes.

These tropical perennials are grown for their ornamental foliage. They are mostly natives of tropical America. They are compact and usually do not exceed 12 inches (30 cm) in height. They vary considerably in appearance. Some have threadlike, trailing stems and some have fleshy, stout stems. The leaves are smooth and fleshy and may be oval with the leafstalk at or near the center of the leaf blade, or they may be heart-shaped or lance-shaped; their size may vary from 1–4 inches (2.5–10.2 cm) long. They may be green or striped, marbled or bordered with pale green, red or gray, and the petioles of some kinds are red. The tiny flowers are unnoticeable and they grow in the form of cordlike spikes. The fruit is a berry that eventually dries out and shows the pepper-like seed